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KMID : 0357920110450000101
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Korean Journal of Pathology
2011 Volume.45 No. 0 p.101 ~ p.105
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Dedifferentiated Extraskeletal Myxoid Chondrosarcoma of the Masticator Space - A Case Report -
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Jung Geun-Young
Cho Kyung-Ja
Choi Seung-Ho
Kim Mi-Jung
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Abstract
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We describe a 69-year-old woman who presented with a dedifferentiated extraskeletal myxoid chondrosarcoma arising in the left masticator space. Computed tomography and magnetic resonance imaging revealed a 5 cm sized mass in the left masticator space. Histologically, the tumor consisted of two distinct areas. The less cellular area was a low-grade extraskeletal myxoid chondrosarcoma, composed of strands or cords of uniform spindle cells and abundant myxoid stroma. The more cellular, dedifferentiated area corresponded to a high grade myxofibrosarcoma, consisting of anaplastic tumor cells in myxoid stroma and geographic necrosis. The tumor cells of the former area were positive for S-100 protein, microtubule-associated protein-2 (MAP-2) and class III β-tubulin, but negative for cytokeratin, smooth muscle actin, and desmin. The tumor cells in the latter, pleomorphic area showed MAP-2 and β-tubulin immunoreactivity with a high Ki-67 labeling index. Based on its histologic and immunohistochemical features, the tumor was considered a dedifferentiated extraskeletal myxoid chondrosarcoma.
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KEYWORD
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Extraskeletal myxoid chondrosarcoma, Cell dedifferentiation, Masticator space
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